These include internal parasites, coccidiosis, changes in diet especially after a drought, and bacterial and viral infections of the gastrointestinal tract. This is true both in cases where diseases associated with selenium deficiency are endemic in areas of low selenium consumption, such as keshan disease. Signs and symptoms of selenium toxicity are you taking too. Another test a healthcare professional can carry out is to test ones levels of glutathione peroxidase or other selenoproteins that need selenium to. The major dietary source of selenium is plant foods. We read with interest the article by inoko et al about selenium deficiency,1 but we do not agree with the interpretation of the data. At presentation, his serum selenium level was less than 2. Other symptoms associated with selenium deficiency include muscle weakness, heart problems, muscle wasting and reoccurring illnesses such as the flu. The following compilations may help in diagnosing and treating these deficiencies. Other parts of your skin can start to change color, leading to pigmentation issues. Hoof disorders were noted in livestock in colombia in 1560 and in south dakota u. The symptoms of kbd include joint pain, morning stiffness in the joints, disturbances of flexion and extension in the elbows, enlarged interphalangeal joints, and limited motion in many joints of the body. In humans, there are several examples of disease that can be attributed to selenium deficiency, and for some, the ultimate causal relationship has been established by the demonstration that symptoms can be alleviated with selenium supplementation of the at risk population. Selenium deficiency and human disease springerlink.
Fatigue, muscle weakness and pain, hair or skin discoloration and miscarriage can also be some of the signs of this condition. Selenium deficiency is diagnosed by postmortem examination or a blood test or responses to. Selenium deficiency in soils and crops and its impact on animal. This typically happens in combination with an iodine deficiency. Consuming a traditional korean diet largely based on grains and vegetables may contribute to the risk of marginal zinc deficiency in korea 17. Keshan disease occurs only in selenium deficient children and is associated with an. Selenium deficiency occurs in cattle and sheep grazing on low selenium soils in the uk unless supplementation is provided. Selenium deficiency disorders of nutrition merck manuals. Disease conditions associated with selenium deficiency. The us department of energys program for climate model diagnosis. Many of the symptoms are therefore the same as those of an underactive thyroid. With selenium deficiency, the bed of your fingernails will start to change color. Chronic selenium deficiency has been linked to mental retardation, heart disease, cancer, asthma, and rheumatoid arthritis 3. Symptoms of a thyroid problem include these signs and symptoms.
Selenium deficiency nutritional disorders msd manual. Selenium deficiencies can cause white muscle disease, heart failure, paralysis, lower birth rates, weak or stillborn calves, and lower overall immunity. Selenium deficiency symptoms, causes and treatments dr. His skin symptoms were similar to those attributable to a deficiency of zinc which, like selenium, is an essential trace element. Selenium deficiency may be implicated as the predominant issue where liver damage is the primary presenting sign. Selenium deficiency occurs when an organism lacks the required levels of selenium, a critical nutrient in many species. It also plays a critical role in increasing the immune response.
Selenium and selenium deficiency goes along with vitamin e but vitamin e will be the primary focus of this article. Selenium benefits, foods, dosage and side effects dr. Jul 09, 2020 selenium deficiency is not spoken about or given the same weightage as vitamins b and d. Selenium deficiency and viral infection the journal of. Without enough selenium, the thyroid gland cannot synthesize iodothyronine deiodinase. Because this micronutrient is the essential factor of glutathione peroxidase synthesis and is involved in various metabolic processes, it may predispose individuals to various diseases. In certain areas of china, where intake averages 10 to 15 mcgday, selenium deficiency predisposes patients to keshan disease, an endemic viral cardiomyopathy affecting primarily. It is fundamental to human health and found in many foods. The signs of selenium deficiency include skeletal myopathy and cardiomyopathy, and selenium deficiency continues to be reported in cases in which this essential element has not been added to parenteral nutrition solutions during longterm administration 70. Aug 14, 2020 hair loss selenium deficiency can also cause hair loss which means many people with hair loss use selenium. In cattle, sheep, and goats, selenium deficiency also can cause abortion, stillbirth, or death shortly after birth. Selenium supplementation strategies for livestock in oregon. Selenium is a naturally occurring substance that is toxic at high concentrations but is also a nutritionally essential.
Deficiency, although relatively rare in healthy wellnourished individuals, can have significant negative results, affecting the health of the heart and the nervous system. Nonetheless, it is equally essential for various bodily functions such as dna synthesis, reproduction. Selenium deficiency is known to cause problems for many systems of the body including the cardiovascular system, the immune system and the endocrine system. Nadis animal health skills vitamin e selenium deficiency.
Hypothyroidism or inactive thyroid gland is also a symptom of selenium deficiency, which happens because selenium helps in conversion of thyroid hormone t4 to hormone t3. Selenium deficiency risk predicted to increase under future. Brazil nuts, eggs, sunflower seeds, liver, fish, turkey, chicken breast, chia seeds and mushrooms. His skin lesions responded well to supplementary treatment with sodium selenite. Just be sure that your dose isnt too high or you may cause the same problem. Selenium deficiency is rare, even in new zealand and finland, where selenium intake is 30 to 50 mcgday, compared with 100 to 250 mcgday in the us and canada.
Selenium deficiency in sheep department of primary. Sep 17, 2018 selenium deficiency might also influence cognitive functioning, but again, more research is needed in this area. Brittle nails selenium toxicity can cause changes to your nail beds including discoloration in your nails. Unexplained weight gain can be indicative of an individual affected by selenium deficiency. Selenium deficiency causes diseases in animals and human. However, increased metabolic requirements for indicated deficiencies may persist for a long time after the outward symptoms have disappeared.
Research health effects, dosing, sources, deficiency symptoms, side effects, and interactions here. Feb 02, 2016 selenium is an essential mineral and micronutrient. Selenium deficiency may work with iodine deficiency to cause a goiter and an underactive thyroid gland hypothyroidism in people who have both deficiencies. Sep 01, 2020 selenium selenium is necessary for the development of the pancreas and the integrity of cell membranes.
Learn more about the signs of selenium deficiency and why it might. Selenium deficiency risk predicted to increase under future climate. Three specific diseases have been associated with selenium deficiency. One of the most important things on selenium s todo list. Selenium deficiency has been implicated in cardiovascular disease, infertility, myodegenerative diseases, and cognitive decline. Selenium deficiency an overview sciencedirect topics. Role of selenium journal of pharmaceutical sciences and research. Request pdf selenium deficiency and human disease the beneficial role of selenium became apparent in the 1950s, when it was shown to prevent a variety of diseases in animals, often when. Jun 15, 2020 selenium deficiency can be diagnosed with a blood test, which means recent selenium intake. Selenium selenium is a trace mineral essential to good health.
Suspected deficiency of either vitamin e or selenium can be verified by laboratory testing involving analysis of tissue levels especially in the liver and histopathology of affected organs. This disease may be more common in siberia and china. Eye deficiency symptoms symptom deficiency treatment cause bitots spots foamy patches on conjunctiva vitamin a bloodshot eyes boric acid for fungus infection, blue light blurred vision vitamins b2, b 6, pantothenic acid bulging eyes vitamin e, nicotinamide, iodine. Improving selenium status in plant nutrition and quality. Selenium deficiency symptoms, daily value and how you can. Zinc, copper and selenium tible to zinc deficiency state. Selenium deficiency occurs due to an insufficient dietary intake of selenium. Acute selenium toxicity can cause severe gastrointestinal and neurological symptoms, acute respiratory distress syndrome, myocardial infarction, hair loss, muscle tenderness, tremors, lightheadedness, facial flushing, kidney failure, cardiac failure, and, in rare cases, death 2, 6. The symptoms of the disease make the manual farmwork painful and difficult, and. The risk of zinc deficiency is increased in certain disease states.
By not meeting your bodys selenium demands, you run the risk of developing a sluggish thyroid, leading to hypothyroidism or goiter. Selenium deficiency nutritional disorders merck manuals. However, if the consequences of selenium deficiency in man are now wi. Selenium deficiency in sheep nsw department of primary. Selenium deficiency in cattle agriculture and food. Hair or nail samples can also be taken, which gives an indication of longterm selenium status. However, selenium supplementation in some areas showed no significant effect, meaning that deficiency of selenium may not be the dominant cause in kbd. Recently a significant association between snp rs6910140 of col9a1 and kashinbeck disease was discovered genetically, suggesting a role of col9a1 in the development of kashinbeck disease. Influenza is an rna virus in the orthomyxoviridae family with a segmented genome. Warning symptoms of selenium deficiency and how to avoid it. Growing children with selenium deficiency may develop a slowly progressive, disabling disorder of the joints and bone kashinbeck disease. Jan 25, 2017 in men, being selenium deficient may bring on mortality of sperm.
It may be entirely possible that the symptoms of selenium deficiency may actually be mediated through their effects on your thyroid. Theyll look more white, instead of the normal color of your skin. As selenium is crucial for the normal function of our immune system, hair, thyroid and other organs, a deficiency can cause a weakened immune response an. Muth disease, which causes damage accompanied by a whitish coloration in muscles of the limbs or heart. Doctors suspect selenium deficiency based on the persons circumstances and symptoms. Selenium in soils and crops, its deficiencies in livestock and humans. Pdf overview of selenium deficiency and toxicity worldwide. Selenium deficiency is associated with cardiomyopathy and congestive heart failure in geographic areas where dietary selenium intake is low. This white color wont grow upwards with the nail and is usually actually within the bed and the skin around it. It is required in cattle for normal growth and fertility and for helping to prevent other health disorders such as mastitis and calf scours. Selenium concentrations in plants generally relect the concentration of selenium in soils, but some meats and seafood can also contribute dietary selenium.
In certain areas of china, where intake averages 10 to 15 mcgday, selenium deficiency predisposes patients to keshan disease, an endemic viral cardiomyopathy. Selenium deficiency regions in new zealand, denmark and the atlantic region of. Selenium is an important mineral for many of your bodys functions. Eye, hair, nail, mouth and skin symptoms are among the early outward warning signs of vitamin and mineral deficiencies. This symptom stems directly from the effect an inadequate supply of selenium has on the function of the thyroid gland. Include selenium foods in your diet to help bring levels up. Selenium deficiency was identified as a factor in the etiology. Selenium deficiency has been shown to directly impair thyroid hormone production from the thyroid gland and it may reduce the peripheral conversion of t4 thyroid hormone into the active t3 thyroid hormone 9. Selenium deficiency can produce a range of symptoms. Selenium deficiency and toxicity in the environment nerc open. Selenium is an essential trace element with fundamental effects on human biology. Keshan disease, a potentially fatal cardiomyopathy with myocardial necrosis results from a combination of selenium deficiency from poor dietary intake and. In human its deficiency called keshan disease and in animals called white muscle disease.
Selenium is undoubtedly an essential trace element. Selenium linus pauling institute oregon state university. Trace elements deficiency is not an uncommon finding in autoimmune diseases. Two important ones include white muscle disease, which occurs primarily in foals, and equine motor neuron disease, which affects adults. Some epidemiological studies have suggested that selenium deficiency may contribute to cardiovascular disease in humans. Deficiency in selenium can cause a variety of symptoms in horses, including myopathy muscle disease, impaired movement, difficulty in suckling. Signs and symptoms of selenium toxicity are you taking. Apr 24, 2018 selenium is essential for thyroid hormone synthesis and metabolism. Selenium deficiency dietary sources, causes, signs. Symptoms of selenium deficiency the diseases associated with selenium deficiency are listed in table 1.
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